abstract：AIMS:This study evaluated the evolution of the prenatal diagnosis of congenital heart disease (CHD) between 2003 and 2008 and its repercussion for the CHD prevalence rate at birth in a well-defined population (Canton of Vaud, Switzerland). METHODS AND RESULTS:All 572 cases of CHD reported in the Eurocat Registry of Va...

journal_title：Swiss medical weekly

authors： Rossier MC,Mivelaz Y,Addor MC,Sekarski N,Meijboom EJ,Vial Y

更新日期：2014-12-04 00:00:00

abstract：:In the coming decades, old patients will account for an increasing proportion of emergency department (ED) visits. During or after their stay in the ED, they more frequently suffer adverse outcomes than younger patients. There is evidence that specific age-centred approaches improve the outcomes. We therefore reviewed...

journal_title：Swiss medical weekly

authors： Schoenenberger AW,Exadaktylos AK

更新日期：2014-12-04 00:00:00

abstract：BACKGROUND:The Swiss Monitoring of Potential Organ Donors (SwissPOD) was initiated to investigate the causes of the overall low organ donation rate in Switzerland. The objective of our study was an assessment of the donation after brain death (DBD) process in Swiss adult intensive care units (ICUs), and to provide an o...

journal_title：Swiss medical weekly

authors： Weiss JH,Keel I,Immer FF,Wiegand J,Haberthür C,Comité National du Don d'Organes (CNDO).

更新日期：2014-10-23 00:00:00

abstract：QUESTIONS UNDER STUDY:To improve the response of deteriorating patients during their hospital stay, the University Hospital Bern has introduced a Medical Emergency Team (MET). Aim of this retrospective cohort study is to review the preceding factors, patient characteristics, process parameters and their correlation to ...

journal_title：Swiss medical weekly

authors： Etter R,Takala J,Merz TM

更新日期：2014-10-08 00:00:00

abstract：:The endoplasmic reticulum (ER) is an intracellular compartment dedicated to the synthesis and maturation of secretory and membrane proteins, totalling about 30% of the total eukaryotic cells proteome. The capacity to produce correctly folded polypeptides and to transport them to their correct intra- or extracellular d...

journal_title：Swiss medical weekly

authors： Noack J,Brambilla Pisoni G,Molinari M

更新日期：2014-08-21 00:00:00

abstract：QUESTION UNDER STUDY:To investigate the change over time in the number of ED admissions with positive blood alcohol concentration (BAC) and to evaluate predictors of BAC level. METHODS:We conducted a single site retrospective study at the ED of a tertiary referral hospital (western part of Switzerland) and obtained al...

journal_title：Swiss medical weekly

authors： Bertholet N,Adam A,Faouzi M,Boulat O,Yersin B,Daeppen JB,Clerc D

更新日期：2014-08-07 00:00:00

abstract：BACKGROUND:On 1 January 2012 Swiss Diagnosis Related Groups (DRG), a new uniform payment system for in-patients was introduced in Switzerland with the intention to replace a "cost-based" with a "case-based" reimbursement system to increase efficiency. With the introduction of the new payment system we aim to answer que...

journal_title：Swiss medical weekly

authors： Thommen D,Weissenberger N,Schuetz P,Mueller B,Reemts C,Holler T,Schifferli JA,Gerber M,Hug BL

更新日期：2014-06-25 00:00:00

abstract：:Osteoarticular infections remain a significant cause of morbidity worldwide in young children. They can have a devastating impact with a high rate of serious and long-lasting sequelae, especially on remaining growth. Depending on the localisation of infection, they manifest as osteomyelitis, septic arthritis, a combin...

journal_title：Swiss medical weekly

authors： Ceroni D,Kampouroglou G,Valaikaite R,Anderson della Llana R,Salvo D

更新日期：2014-06-12 00:00:00

abstract：:Osteoporosis is complicated by the occurrence of fragility fractures. Over past years, various treatment options have become available, mostly potent antiresorptive agents such as bisphosphonates and denosumab. However, antiresorptive therapy cannot fully and rapidly restore bone mass and structure that has been lost ...

journal_title：Swiss medical weekly

authors： Meier C,Lamy O,Krieg MA,Mellinghoff HU,Felder M,Ferrari S,Rizzoli R

更新日期：2014-06-04 00:00:00

abstract：:In his 1966 monograph "Charcot joints", Sidney N. Eichenholtz (1909-2000) described "three well defined stages … in the course and development of a Charcot joint", based on plain X-rays of 68 patients. Since then, medical imaging has advanced very much: computed tomography and magnetic resonance imaging (MRI) scans ex...

journal_title：Swiss medical weekly

authors： Chantelau EA,Grützner G

更新日期：2014-04-24 00:00:00

abstract：BACKGROUND:Neuroendocrine neoplasms (NENs) are difficult to diagnose. We used SwissNET data to characterise NEN patients followed in the two academic centres of western Switzerland (WS), and to compare them with patients followed in eastern Switzerland (ES) as well as with international guidelines. METHOD:SwissNET is ...

journal_title：Swiss medical weekly

authors： Gouffon M,Iff S,Ziegler K,Larche M,Schwarzenbach C,Prior JO,Matter M,Stettler C,Pralong FP

更新日期：2014-02-19 00:00:00

abstract：:Minimal residual disease (MRD) refers to the small number of malignant cells that remain after therapy when the patient is in remission and shows no symptoms or overt signs of disease. Current treatment protocols for haematological malignancies allow most patients to obtain some form of MRD state, but cure seldom foll...

journal_title：Swiss medical weekly

authors： Hauwel M,Matthes T

更新日期：2014-01-22 00:00:00

abstract：BACKGROUND:The European Consensus Statement of Neonatal Hearing recommended universal newborn hearing screening (UNHS) in 1998. UNHS was introduced in Switzerland in 1999 under the auspices of a "Swiss Working Group Hearing Screening in Newborns". The aim of this study was to evaluate the number of newborns being scree...

journal_title：Swiss medical weekly

authors： Metzger D,Pezier TF,Veraguth D

更新日期：2013-12-13 00:00:00

abstract：:Mantle cell lymphoma (MCL) is a relatively rare lymphoma entity accounting for an estimated 3%-6% of all non-Hodgkin's lymphoma cases. Characterised by both the incurability of indolent lymphomas and the rapid growth of aggressive lymphomas, MCL has a median overall survival of only 4-5 years. Although the disease oft...

journal_title：Swiss medical weekly

authors： Hitz F,Bargetzi M,Cogliatti S,Lohri A,Taverna C,Renner C,Mey U

更新日期：2013-11-13 00:00:00

abstract：QUESTION UNDER STUDY:Type 2 diabetes mellitus (T2Dm) is a chronic disease with great economic impact. In 2009, the Swiss Society for Endocrinology and Diabetes (SSED) published recommendations for treatment of T2Dm. In Switzerland, few data are currently available on metabolic control and physician compliance with trea...

journal_title：Swiss medical weekly

authors： Burgmann K,Fatio S,Jordi B,Rutishauser J

更新日期：2013-10-25 00:00:00

abstract：BACKGROUND:Although most experts recommend empirical antibiotic treatment, covering also atypical bacteria, for patients admitted to an intensive care unit (ICU), the data are not clear for patients admitted to a general ward. European guidelines recommend starting empirical treatment with a beta-lactam antibiotic with...

journal_title：Swiss medical weekly

authors： Piso RJ,Arnold C,Bassetti S

更新日期：2013-09-19 00:00:00

abstract：INTRODUCTION:Selection of medical students varies between German- and French-speaking Swiss faculties. Geneva introduced an aptitude test in 2010, aimed at helping decision making among students. The test was compulsory: it had to be taken by those who intended to register for medical studies. But it was not selective:...

journal_title：Swiss medical weekly

authors： Cerutti B,Bernheim L,van Gessel E

更新日期：2013-09-19 00:00:00

abstract：OBJECTIVES:Several studies have reported prolonged QTc intervals in patients under methadone maintenance treatment, including development of torsade-de-pointes arrhythmia and death. It is still not clear why some patients develop critical QTc extensions while others do not. METHODS:ECG findings in a convenience sample...

journal_title：Swiss medical weekly

authors： Gholami N,Boesch L,Falcato L,Stohler R,Bruggmann P

更新日期：2013-09-06 00:00:00

abstract：BACKGROUND:Hypoxia-inducible factor-1α (HIF-1α) plays an important role in tumour progression and metastasis through activation of many target genes that are especially involved in pivotal aspects of cancer biology. However, the prognostic role of HIF-1α has been controversial in primary patients with lung cancer. This...

journal_title：Swiss medical weekly

authors： Ren W,Mi D,Yang K,Cao N,Tian J,Li Z,Ma B

更新日期：2013-09-06 00:00:00

abstract：BACKGROUND:Preventive treatment may avoid future cases of tuberculosis among asylum seekers. The effectiveness of preventive treatment depends in large part on treatment completion. METHODS:In a prospective cohort study, asylum seekers of two of the Swiss Canton Vaud migration centres were screened with the Interferon...

journal_title：Swiss medical weekly

authors： Sarivalasis A,Bodenmann P,Langenskiold E,Lutchmaya-Flick C,Daher O,Zellweger JP

更新日期：2013-09-06 00:00:00

abstract：PRINCIPALS:Accidents in agriculture are a problem of global importance. The hazards of working in agriculture are manifold (machines, animals, heights). We therefore assessed injury severity and mortality from accidents in farming. METHODS:We retrospectively analysed all farming accidents treated over a 12-year period...

journal_title：Swiss medical weekly

authors： Pfortmueller CA,Kradolfer D,Kunz M,Lehmann B,Lindner G,Exadaktylos A

更新日期：2013-08-27 00:00:00

abstract：QUESTIONS UNDER STUDY:In Switzerland, skin cancer is one of the most prevalent neoplasms. General practitioners (GPs) are often faced with suspicious skin lesions in their patients. The aim of our study was to assess GPs' competence to diagnose skin cancer and to examine whether this can be improved by a one-day dermat...

journal_title：Swiss medical weekly

authors： Badertscher N,Braun RP,Held U,Kofmehl R,Senn O,Hofbauer GF,Rossi PO,Wensing M,Rosemann T,Tandjung R

更新日期：2013-07-29 00:00:00

abstract：BACKGROUND:Endoscopic retrograde biliary drainage (ERBD) using a plastic stent is suggested to be as effective as endoscopic nasobiliary drainage (ENBD) with a nasobiliary catheter for temporary biliary drainage in acute obstructive cholangitis. However, there are few studies that have compared the two methods. We ther...

journal_title：Swiss medical weekly

authors： Zhang RL,Cheng L,Cai XB,Zhao H,Zhu F,Wan XJ

更新日期：2013-07-07 00:00:00

abstract：OBJECTIVES:To describe alcohol and tobacco consumption during pregnancy in women giving birth in a public hospital in Geneva, to evaluate risk factors related to these consumptions and to explore the influence of close relatives on the consumption habits of pregnant women. METHODS:A cross-sectional questionnaire surve...

journal_title：Swiss medical weekly

authors： Dupraz J,Graff V,Barasche J,Etter JF,Boulvain M

更新日期：2013-05-25 00:00:00

abstract：OBJECTIVE:To examine the demographics, evolution and outcome of patients suffering from malignancies admitted to a medical intensive care unit. PATIENTS AND METHODS:Single centre retrospective cohort study of patients with malignancies. Data on demographics, diagnosis laboratory tests, provided therapy and outcome wer...

journal_title：Swiss medical weekly

authors： Unseld S,Schuepbach RA,Maggiorini M

更新日期：2013-03-26 00:00:00

abstract：QUESTIONS UNDER STUDY/PRINCIPLES:Although probe-based confocal laser endomicroscopy (pCLE) is on the edge of entering daily practice in gastroenterological endoscopy, findings in the field of respiratory medicine are only rarely reported, keeping pCLE during flexible bronchoscopy as a mere preclinical research tool. Si...

journal_title：Swiss medical weekly

authors： Yserbyt J,Dooms C,Ninane V,Decramer M,Verleden G

更新日期：2013-03-26 00:00:00

abstract：:Cells reside in mechanically rich and dynamic microenvironments, and the complex interplay between mechanics and biology is widely acknowledged. Recent research has yielded insights linking the mechanobiology of cells, human physiology, and pathophysiology. In particular, we have learned of the cell's astounding abili...

journal_title：Swiss medical weekly

authors： Steward RL Jr,Rosner SR,Zhou EH,Fredberg JJ

更新日期：2013-03-14 00:00:00

abstract：:Vascular procedures are rarely complicated by infection, but if prosthetic vascular graft infection (PVGI) occurs, morbidity and mortality are high. Several patient-related, surgery-related and postoperative risk factors are reported, but they are not well validated. PVGI is due to bacterial colonisation of the wound ...

journal_title：Swiss medical weekly

authors： Hasse B,Husmann L,Zinkernagel A,Weber R,Lachat M,Mayer D

更新日期：2013-01-24 00:00:00

abstract：QUESTIONS UNDER STUDY:To evaluate the diagnostic value of serum Cystatin C and urine neutrophil gelatinase-associated lipocalin (NGAL) for the detection of acute kidney injury in patients undergoing congenital heart surgery. METHODS:Serial samples of serum Cystatin C and urine NGAL were collected from 139 consecutive ...

journal_title：Swiss medical weekly

authors： Seitz S,Rauh M,Gloeckler M,Cesnjevar R,Dittrich S,Koch AM

更新日期：2013-01-17 00:00:00

abstract：BACKGROUND:The pathogenesis of elevated blood pressure and other cardiovascular risk factors in the population and their progression over time is still incompletely understood, especially in young and healthy adults. METHODS:The genetic and phenotypic determinants of blood pressure and other cardiovascular risk factor...

journal_title：Swiss medical weekly

authors： Conen D,Schön T,Aeschbacher S,Paré G,Frehner W,Risch M,Risch L

更新日期：2013-01-08 00:00:00

abstract：BACKGROUND:In 2005, findings of the first "cost of disorders of the brain in Europe" study of the European Brain Council (EBC) showed that these costs cause a substantial economic burden to the Swiss society. In 2010 an improved update with a broader range of disorders has been analysed. This report shows the new findi...

journal_title：Swiss medical weekly

authors： Maercker A,Perkonigg A,Preisig M,Schaller K,Weller M,Cost of Disorders of the Brain in Europe Study Group.

更新日期：2013-01-07 00:00:00

abstract：QUESTIONS UNDER STUDY / PRINCIPLES:Colonoscopies are complex procedures that depend greatly on the patient's cooperation and on the correct judgment of a tolerable amount of discomfort by the endoscopy team, even in sedated patients. Little is known regarding the accuracy of the patient comfort level assessments made b...

journal_title：Swiss medical weekly

authors： Heuss LT,Sughanda SP,Degen LP

更新日期：2012-11-05 00:00:00

abstract：:After the health catastrophe resulting from the widespread use of asbestos which was once hailed as a new miracle material, the increasing use of carbon nanotubes (CNTs) has spawned major concern due to their similarities in terms of size, shape and poor solubility. Assessment of genotoxicity has shown that CNTs can d...

journal_title：Swiss medical weekly

authors： van Berlo D,Clift MJ,Albrecht C,Schins RP

更新日期：2012-11-05 00:00:00

abstract：:Meningitis due to Streptococcus pneumoniae is a rare complication of trans-sphenoidal surgery. We present the case of a patient who developed pneumococcal meningitis with associated bacteraemia after elective endoscopic trans-sphenoidal resection of a pituitary macro-adenoma. After initial treatment with ceftriaxone a...

journal_title：Swiss medical weekly

authors： Darling KE,Niederhauser J,Bervini D,Giulieri S,Daniel RT,Bille J,Erard V

更新日期：2012-10-29 00:00:00

abstract：STUDY/PRINCIPLES:Physical activity improves the clinical course of the metabolic syndrome and its risk factors. The aim of this study was to investigate the physical activity behaviour in patients with metabolic syndrome in regard to the recommendation of the Federal Offices of Public Health (BAG) and Sports (BASPO): "...

journal_title：Swiss medical weekly

authors： Murer M,Schmied C,Battegay E,Keller DI

更新日期：2012-10-25 00:00:00

abstract：:New oral anticoagulants used as single target inhibitors of coagulation enzymes have been developed and tested in extensive trial programmes. Results of most of these trials showed non-inferior and/or superior efficacy and safety compared to standard treatment with LMWH or VKA. These results led to registration of the...

journal_title：Swiss medical weekly

authors： Graf L,Tsakiris DA

更新日期：2012-10-01 00:00:00

abstract：:Rehabilitation can be referred to as a "black box" because little is known about what specific interventions comprise the rehabilitation process, including patients with spinal cord injury (SCI). Despite that rehabilitation professionals can "see" daily what rehabilitation looks like, the contribution of each interven...

journal_title：Swiss medical weekly

authors： van Hedel HJ

更新日期：2012-09-20 00:00:00

abstract：:Prior to the introduction of chemotherapy, tuberculosis management relied upon aerotherapy, heliotherapy and good nutrition. This "treatment", exemplified by the regimen applied in Swiss and other European mountain resorts, is described by Thomas Mann in the book "The Magic Mountain". Tuberculosis chemotherapy began i...

journal_title：Swiss medical weekly

authors： Diacon AH,von Groote-Bidlingmaier F,Donald PR

更新日期：2012-08-22 00:00:00

abstract：QUESTIONS UNDER STUDY:In HIV-infected patients, comprehension of medication instructions is an essential condition for adherence to Highly Active Antiretroviral Therapy (HAART). In this study, we used a self-reported questionnaire to know which sources of medication information HIV-infected patients used and their impa...

journal_title：Swiss medical weekly

authors： Korb-Savoldelli V,Gillaizeau F,Caruba T,Tauckoor A,Prognon P,Durieux P,Sabatier B

更新日期：2012-07-26 00:00:00

abstract：QUESTIONS UNDER STUDY:Suicidal behaviour is a major source of burden of disease. While most studies focus on cost associated with completed suicides, data on costs of, non-lethal, suicide attempts are lacking. The aim of this study was to assess direct annual cost of suicide attempts in Basel in 2003 from a health serv...

journal_title：Swiss medical weekly

authors： Czernin S,Vogel M,Flückiger M,Muheim F,Bourgnon JC,Reichelt M,Eichhorn M,Riecher-Rössler A,Stoppe G

更新日期：2012-07-23 00:00:00